Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Patch Clamp01:18

Patch Clamp

5.3K
Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
5.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Decoding the mechanisms of amyloid-β in synaptic toxicity.

Journal of Alzheimer's disease : JAD·2026
Same author

Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes.

Nature communications·2026
Same author

Importance of early access to language: theory of mind in school-aged children with cochlear implants.

Cochlear implants international·2025
Same author

Chaperone-Mediated Regulation of Tau Phase Separation, Fibrillation, and Toxicity.

Journal of the American Chemical Society·2025
Same author

CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.

Science advances·2024
Same author

Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone.

ACS chemical neuroscience·2023

相关实验视频

Updated: May 21, 2025

A Computer-assisted Multi-electrode Patch-clamp System
11:01

A Computer-assisted Multi-electrode Patch-clamp System

Published on: October 18, 2013

13.7K

通过"Auto ANT"进行高效,自动和可重复的补丁数据分析,这是一个用户友好的界面,用于批量分析补丁记录.

Giusy Pizzirusso1,2, Simon Sundström3, Luis Enrique Arroyo-García4

  • 1Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 17177, Solna, Sweden. giusy.pizzirusso@ki.se.

Neuroinformatics
|March 19, 2025
PubMed
概括

本研究介绍了Auto ANT,这是一个开源软件,可以自动化补丁数据分析. 它提供了一种快速,可重复的方法,可以从可刺激的细胞中提取电性质.

关键词:
行动潜力 行动潜力分析 分析 分析自动化 自动化 自动化内在的属性 内在的属性.补丁门 - 补丁门

更多相关视频

Application of Automated Image-guided Patch Clamp for the Study of Neurons in Brain Slices
09:05

Application of Automated Image-guided Patch Clamp for the Study of Neurons in Brain Slices

Published on: July 31, 2017

11.4K
One-channel Cell-attached Patch-clamp Recording
13:07

One-channel Cell-attached Patch-clamp Recording

Published on: June 9, 2014

24.2K

相关实验视频

Last Updated: May 21, 2025

A Computer-assisted Multi-electrode Patch-clamp System
11:01

A Computer-assisted Multi-electrode Patch-clamp System

Published on: October 18, 2013

13.7K
Application of Automated Image-guided Patch Clamp for the Study of Neurons in Brain Slices
09:05

Application of Automated Image-guided Patch Clamp for the Study of Neurons in Brain Slices

Published on: July 31, 2017

11.4K
One-channel Cell-attached Patch-clamp Recording
13:07

One-channel Cell-attached Patch-clamp Recording

Published on: June 9, 2014

24.2K

科学领域:

  • 电子生理学 电子生理学
  • 计算神经科学是一种神经科学.
  • 生物物理学的生物物理.

背景情况:

  • 补丁的记录对于研究可激发细胞的电性质至关重要.
  • 手动分析这些记录是耗时的,容易变化.

研究的目的:

  • 开发一个自动化,用户友好的软件来分析补丁录音.
  • 为了简化提取燃烧和被动膜属性的提取.
  • 提高电生理学数据分析的可复制性和效率.

主要方法:

  • 开发Auto ANT (自动化分析和表格) 开源软件.
  • 实现图形用户界面以方便使用.
  • 包含针对多个记录的批量分析功能.

主要成果:

  • 自动ANT自动提取发射和被动膜特性.
  • 该软件可以在几分钟内对多个补丁文件进行批量分析.
  • 为手动分析提供了一个快速,高效和可重复的替代方案.

结论:

  • 自动ANTT加速了电生理学数据分析.
  • 该软件促进了研究中的一致性和可重复性.
  • 它使得没有编程专业知识的研究人员能够进行全面的分析.