氧化平衡得分与代谢综合征患者的死亡率之间的关联
Yu-Qing Li1, Ping Li1, Ran Chu1
1Clinical School of Thoracic, Tianjin Medical University, No.22 Qi Xiangtai Road, Heping District, Tianjin, 300070, People's Republic of China.
Scientific reports
|March 19, 2025
概括
保持均衡的抗氧化剂摄入量和健康的生活习惯与代谢综合征 (MetS) 患者的死亡风险降低有关. 这种氧化平衡得分 (OBS) 强调了饮食和生活方式对于更好的健康结果的重要性.
科学领域:
- 心血管研究研究心血管研究
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 氧化应激和慢性炎症与代谢综合征 (MetS) 的发展和进展有关.
- 氧化平衡评分 (OBS) 量化了氧化应激,但其与MetS患者死亡率的联系尚未得到充分证实.
研究的目的:
- 调查氧化平衡评分 (OBS) 与所有原因和心血管疾病死亡率在大批MetS患者中之间的关联.
- 评估导致氧化平衡的饮食和生活方式因素对MetS人群中死亡风险的影响.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (1999-2018) 中对10,647名MetS患者的分析.
- 基于16种饮食和4种生活方式因素计算OBS.
- 使用多变量Cox比例危险回归,卡普兰-梅尔分析和受限立方线 (RCS) 进行生存分析.
主要成果:
- 在MetS患者中,观察到较高的OBS和降低所有原因和心血管死亡风险之间存在显著的反向关联.
- 结果在各个子组中一致,并通过敏感性分析验证.
- 卡普兰-梅尔曲线和RCS分析支持较高OBS的保护作用.
结论:
- 富含抗氧化剂的饮食和健康的生活方式,反映在更高的OBS中,可以显著降低MetS患者的死亡风险.
- 这些结果强调了促进抗氧化剂促进的饮食模式和生活方式修改对MetS管理和预防的临床重要性.
- OBS是评估死亡风险和指导代谢综合征治疗策略的宝贵工具.
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