AFM揭示了酸化对LDL和氧化LDL受体相互作用的差异性影响:在动脉生成中的生物力学含义

Kun Wang1,2, Chenhan Sun2, Hongda Zhuang2,3

  • 1School of Life Sciences, Nanchang University, 999 Xuefu Ave., Honggutan District, Nanchang, 330031, Jiangxi, People's Republic of China.

概括

酸化显著削弱低密度脂蛋白 (LDL) 与其受体 (LDLR) 的结合,但没有氧化LDL (oxLDL) 与食尸受体CD36.6的结合. 这表明在脂蛋白代谢和动脉样硬化中对pH值变化的敏感性不同.

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