甘油三指数与中国老年人脂肪胰腺疾病独立相关
Weinuo Mi1, Yuzhi Zhang2, Qifeng Wang3
1Department of Endocrinology and Metabolism, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
BMC endocrine disorders
|March 19, 2025
概括
脂肪胰腺疾病 (FPD) 在中国老年人中非常普遍. 甘油三糖 (TyG) 指数有效地识别FPD,但不确定其严重程度,尽管将其与其他因素结合起来可以改善诊断.
科学领域:
- 老年学是一门学科.
- 胃肠病学 胃肠病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 脂肪胰腺疾病 (FPD) 在老年人群中越来越多地被认可.
- 腹腔超声波是FPD的常见诊断工具.
- 三甘油糖 (TyG) 指数是胰岛素耐药性的标志物.
研究的目的:
- 为了确定中国老年人 (≥65岁) 中FPD的患病率.
- 探索TyG指数和FPD之间的相关性,包括其严重程度.
- 评估Tyg指数对FPD的诊断能力及其严重程度.
主要方法:
- 从TOPS研究中分析了567名老年参与者 (≥65岁).
- 使用公式计算TyG指数:Ln [TG (mg/dL) × FBG (mg/dL) /2].使用该公式计算TyG指数.
- 通过腹部超声波诊断FPD和胰腺内脂肪沉积 (IPFD);逻辑回归和ROC曲线分析以求相关性和诊断功率.
主要成果:
- 高FPD患病率 (72.66%) 在老年人中,超过一半有中度至重度的FPD.
- TyG指数与FPD独立相关,而不是严重程度. 较高的TyG指数与增加的代谢障碍和FPD患病率相关.
- 泰格指数表明FPD的诊断性能良好;与BMI或NAFLD的结合提高了诊断能力.
结论:
- 在通过超声波诊断的中国老年人 (≥65岁) 中,FPD的流行率很高.
- TyG指数是有效的识别FPD,但不是其严重程度.
- 将TyG指数与其他临床参数结合起来,可以为FPD提供增强的诊断优势.
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