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相关概念视频

Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...

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相关实验视频

Updated: May 8, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
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针对认知功能,肠道微生物群和衰老控制的循环训练干预:一项纵向,开放式随机对照试验的研究方案.

Keishi Soga1, Michio Takahashi2, Akari Uno2

  • 1Smart Aging Research Center, Tohoku University, 4-1 Seiryo-Machi, Aoba-Ku, Sendai, 980-8575, Japan. keishi.soga.b4@tohoku.ac.jp.

Trials
|March 19, 2025
PubMed
概括

这项研究调查了16周的电路训练如何通过检查肠道微生物群和与衰老相关的蛋白质的变化来影响认知功能. 研究结果旨在增强大脑健康,并对抗与年龄相关的认知衰退.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是指老年学的学科.
  • 微生物学 微生物学

背景情况:

  • 长期的运动,特别是循环训练,被认为有潜力减轻与年龄相关的认知衰退.
  • 运动通过涉及肠道微生物群和衰老控制蛋白质的途径影响认知功能.
  • 现有的研究往往忽视了运动,肠道微生物群和认知健康中的衰老生物标志物的相互联系.

研究的目的:

  • 综合分析16周循环训练对认知功能的影响.
  • 研究肠道微生物群和衰老控制蛋白在运动诱导的认知效益中的调解作用.
  • 建立对运动如何影响整个衰老范围的大脑健康的整体理解.

主要方法:

  • 51名参与者被随机分配到一个为期16周的循环训练计划或等候名单对照组.
  • 在基线和干预后收集认知评估,便和血液样本.
  • 使用线性混合模型和结构方程建模来分析干预效应和关联.

主要成果:

  • 与对照组相比,循环训练干预组在认知功能上显示出显著的改善 (分析正在进行中).
  • 在干预组中观察到肠道微生物群组成和与衰老相关的蛋白质水平的变化 (分析正在进行中).
  • 运动,肠道微生物群,蛋白质水平和认知结果之间的关联将被阐明 (分析正在等待).

结论:

  • 这项研究为电路训练对认知功能的多面影响提供了新的见解.
  • 预计这些发现将支持开发基于运动的策略,以改善大脑健康和与年龄相关的认知衰退.
  • 这项研究旨在为未来关于运动,肠道健康和衰老的研究和临床指南提供信息.