美国成年人中的黄酸摄入量,炎症和动脉样硬化心血管疾病风险:一个横截面研究
Qin Hu1, Xiangyu Ma1, Tongjian Cai1
1Department of Epidemiology, Institute of Military Preventive Medicine, Army Medical University (Third Military Medical University), NO. 30 Gaotanyan Street, Chongqing, 400038, People's Republic of China.
Nutrition & metabolism
|March 19, 2025
概括
饮食中的黄类化合物,特别是黄-3-ols,黄和黄类化合物,与降低动脉样硬化心血管疾病 (ASCVD) 风险有关. 像hs-CRP和NLR这样的炎症标志物调解这种保护作用,这表明生活方式和性别影响着黄胺的益处.
科学领域:
- 营养科学 营养科学
- 心血管研究研究心血管研究
- 流行病学 流行病学
背景情况:
- 动脉样性心血管疾病 (ASCVD) 仍然是全球主要的死亡原因.
- 饮食因素,包括黄类药物,越来越多地被认为对心血管健康的作用.
- 了解黄类的特定亚类及其对ASCVD风险的影响至关重要.
研究的目的:
- 调查饮食中摄入全方位黄素及其子类与ASCVD风险之间的关联.
- 探索炎症在黄类药物摄入量与ASCVD之间的关系中的潜在调解作用.
- 检查性别特异性差异和生活方式因素对这种关联的影响.
主要方法:
- 利用了国家健康和营养检查调查 (2017-2018) 中3841名成年人的横截面数据.
- 通过2天的饮食回忆和ASCVD状态通过医疗问卷评估黄类素摄入量.
- 使用后勤回归,子组,调解和受限立方线分析来评估关联.
主要成果:
- 摄入较高的flavan-3-ols,flavones,flavonols和总的flavonoids与降低ASCVD风险相关.
- 这些关联在女性中更为明显,在吸烟者,非酒精消费者,身体不活跃的个人和高血压患者中更为显著.
- 炎症标志物,高灵敏度C反应蛋白 (hs-CRP) 和中性粒细胞与淋巴细胞的比率 (NLR),调解了黄类-ASCVD的联系,显示了剂量反应的减少.
结论:
- 饮食中摄入特定的黄素 (黄-3-,黄,黄) 与ASCVD风险相反相关.
- 通过hs-CRP和NLR测量的炎症在黄类药物的心脏保护作用中起着调解作用.
- 黄类药物对心血管的益处受性别和生活方式因素的影响,因此需要个性化的饮食建议.
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