患有多个假肢关节的患者中甲时性周围假肢关节感染的危险因素:系统性审查和元分析
Yi Li1, Xiaolin Quan2, Cheng Zhou2
1Department of Orthopaedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guoxue Road, Wuhou District, Chengdu, 610041, China.
Journal of orthopaedic surgery and research
|March 19, 2025
概括
患有多个假肢关节的患者,如果他们患有甲素耐药黄金葡萄球菌 (MRSA),类风湿性关节炎 (RA),有史以来使用过类固醇或其他感染,则患第二次周围假肢关节感染 (PJI) 的风险更高. 识别这些危险因素可以帮助预防甲时性PJI.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 周围假肢关节感染 (PJI) 可以影响多个关节,但对多个假肢患者的元慢性PJI的数据有限.
- 了解元慢性PJI的风险因素对于优化临床管理和预防策略至关重要.
研究的目的:
- 在患有多个假肢关节的患者中,探索甲时性周围假肢关节感染 (PJI) 的风险因素.
- 引导和优化临床实践,用于管理患有第二关节PJI风险的患者.
主要方法:
- 在MEDLINE,科学网,科克伦图书馆和EMBASE进行了系统的文献搜索,直到2024年5月.
- 对9项涉及1544名患者的临床研究进行了元分析,以确定元慢性PJI的显著风险因素.
主要成果:
- 甲素耐药黄金葡萄球菌 (MRSA),类风湿性关节炎 (RA),类固醇使用史和之前/正在进行的非周围假肢感染是元慢性PJI的重要风险因素.
- 在甲基慢性和非甲基慢性PJI组之间,没有发现关于修订,年龄,糖尿病或性别的显著差异.
结论:
- 患有MRSA,RA,有史以来使用过类固醇或其他感染的患者面临更高的甲基慢性PJI风险.
- 进一步的研究是必不可少的,以制定有效的管理和预防策略,在多个假肢的患者中,对元慢性PJI进行治疗.
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