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相关概念视频

Teeth01:15

Teeth

280
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
280
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

3.7K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.7K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

4.3K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.3K
Tooth Anatomy01:21

Tooth Anatomy

310
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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相关实验视频

Updated: May 21, 2025

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
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KMT2D 规范了牙面膜的发展.

J-M Lee1, H Jung1, Q Tang1

  • 1Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.

Journal of dental research
|March 19, 2025
PubMed
概括
此摘要是机器生成的。

KMT2D基因对牙质形成至关重要,其破坏会导致小鼠的非完美牙发生. KMT2D直接调节对乳腺母细胞分化和乳发育至关重要的基因.

关键词:
艾梅洛基尼斯的诞生细胞分化的细胞分化.它的表皮质 (epithelium) 是一个表皮质.基因表达的基因表达方式形态发生 (morphogenesis) 是一种形态的产生.牙的生长过程 (odontogenesis)

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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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科学领域:

  • 发展生物学 发展生物学
  • 遗传学 遗传学 是一个
  • 生物化学 生物化学

背景情况:

  • 杏仁生成对于牙质形成和保护至关重要.
  • 乳糖生成的缺陷会导致像乳糖生成不完善这样的情况.
  • KMT2D中的突变与卡布基综合征和牙异常有关,但其在牙形成中的作用尚不清楚.

研究的目的:

  • 调查KMT2D在牙质形成 (牙质生成) 过程中的特定作用.
  • 在小鼠模型中,以KMT2D干扰引起的质缺陷为特征.

主要方法:

  • 生成了一个有条件的淘汰赛小鼠模型,具有外皮特异性的Kmt2d.删除.
  • 使用微计算机断层扫描,扫描电子显微镜,组织学和分子分析分析了质缺陷.
  • 执行RNA测序和CUT&RUN测序以识别KMT2D目标.

主要成果:

  • 在Kmt2d条件淘汰赛中,小鼠表现出100%的透性非完美肌体与低可塑性和低矿物质质.
  • 新生儿Kmt2d-cKO小鼠表现出微妙的尖端变化和延迟的乳腺细胞分化.
  • KMT2D直接准基因,包括Satb1和Sp6,这对乳腺细胞分化至关重要.

结论:

  • KMT2D通过调节氨基酸细胞分化所必需的基因表达,在氨基酸细胞生成中发挥关键作用.
  • 这项研究提供了关于牙面膜发育和卡布基综合征相关牙缺陷的分子机制的见解.