在177后后续治疗的结果Lu-Vipivotide Tetraxetan对于转移性瘤抵抗性前列腺癌:三级癌症中心的经验
Meryam Losee1, Michael Kavanaugh1,2,3, Mofei Liu4
1Department of Imaging, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
The Prostate
|March 19, 2025
概括
大约30%的转移性割抵抗性前列腺癌 (mCRPC) 患者在177Lu-PSMA-617 (LuPSMA) 后接受了后续治疗,主要是cabazitaxel疗程. 在LuPSMA治疗后,PSA50的响应率为28%,并且通常是可以容忍的.
科学领域:
- 在瘤学瘤学.
- 核医学就是核医学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 177Lu-vipivotide tetraxetan (177Lu-PSMA-617,LuPSMA) 已被批准用于转移性割抵抗性前列腺癌 (mCRPC) 后毒素和雄激素受体通路抑制剂治疗.
- 关于LuPSMA治疗后患者的治疗结果的数据有限.
研究的目的:
- 评估接受标准护理LuPSMA的mCRPC患者的临床过程和结果.
- 分析LuPSMA后的mCRPC患者的后续疗法,毒性和响应率.
主要方法:
- 对2022年6月至2024年1月用LuPSMA治疗的146名mCRPC患者的回顾性分析.
- 从电子医疗记录中提取关于后续治疗,毒性和前列腺特异性抗原 (PSA) 反应的数据.
- 血液毒性和支持性护理要求的评估.
主要成果:
- 44%的患者接受了随后的全身治疗,最常见的是基于cabazitaxel的化疗 (n=27).
- 观察到≥3级贫血 (13/35) 和血小板减少 (7/35),其中16名患者需要血液学支持.
- 在LuPSMA后的治疗中,PSA50应答率为28% (10/36),随后治疗的平均整体存活时间为7.6个月.
结论:
- 大约30%的患者接受了LuPSMA后的后续治疗,主要是cabazitaxel疗程.
- 后LuPSMA治疗是可以容忍的,并实现了28%的PSA50响应率.
- 强调需要在LuPSMA治疗后为mCRPC开发新的治疗策略.
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