超强增强器驱动的长非编码RNAPRKCQ-AS1通过与MSI2蛋白相互作用促进神经母细胞瘤瘤发生,并可被小分子化合物向

Sujanna Mondal1, Pei Y Liu1, Janith Seneviratne1

  • 1Children's Cancer Institute Australia and UNSW Centre for Childhood Cancer Research, University of New South Wales, Sydney, NSW, 2052, Australia.

概括

这项研究确定PRKCQ-AS1是驱动MYCN非增强神经母细胞瘤的关键长非编码RNA. 针对PRKCQ-AS1和MSI2蛋白与小分子相互作用,为神经母细胞瘤提供了一种新的治疗策略.

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