相关实验视频

Updated: May 21, 2025

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

血清阿弗拉托克素B1-lysine吸入度和胆囊癌:一个病例对照研究

Ratnakar Shukla¹, Toshikazu Ikoma², Yasuo Tsuchiya³

¹Department of Clinical Research, Sharda School of Allied Health Sciences, Sharda University, Greater Noida, Uttar Pradesh, 201306, India.

Nutrition and cancer

|March 19, 2025

概括

甲素B1 (AFB1) 暴露与胆囊癌 (GBC) 有关. GBC患者的血清AFB1水平明显高于慢性胆囊炎患者或健康人群,这表明潜在的风险因素.

科学领域:

毒理学毒理学毒理学
胃肠病学胃肠病学
在瘤学瘤学.

背景情况:

非洲毒素B1 (AFB1) 是一种已知的致癌物质,主要与肝癌有关.
新出现的证据表明,AFB1暴露与胆囊癌 (GBC) 之间存在潜在联系.

研究的目的:

为了研究血清AFB1水平和GBC之间的关联.
将GBC患者的AFB1水平与慢性胆囊炎 (CC) 患者和健康受试者 (HS) 的水平进行比较.

主要方法:

从45名GBC患者,57名CC患者和55名HS患者收集了血清样本.
血清AFB1-lysine adduct水平使用ELISA进行了量化.
检测频率和水平在三个组之间进行了比较.

主要成果:

在71%的GBC患者,39%的CC患者和7%的HS患者中检测到AFB1 (p < 0.001).
在GBC患者中,AFB1检测的几率明显高于CC患者 (4.1x) 和HS患者 (16.8x).
血清AFB1水平的中位数在GBC患者 (5.0 ng/mL) 与CC患者 (<0.1 ng/mL) 和HS患者 (<0.1 ng/mL) 相比显著更高.

结论:

直接证据表明,AFB1暴露与在印度发展GBC的风险增加有关.
血清AFB1水平升高是GBC风险的潜在生物标志物.
需要进一步的研究来阐明AFB1诱导的GBC背后的机制.

更多相关视频

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

相关概念视频

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Gallbladder

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...