标准或瘤保护乳腺手术后的存活率与乳腺癌乳腺切除术后的存活率
Mhairi Mactier1,2, James Mansell3, Laura Arthur4
1Wolfson Wohl Cancer Research Centre, College of Medicine and Veterinary Science, University of Glasgow, Glasgow, UK.
BJS open
|March 19, 2025
概括
与放射疗法进行的乳腺保护手术,包括瘤塑料技术,与乳腺切除术相比,为乳腺癌患者提供更好的生存结果. 这一发现支持乳腺保护性手术作为首选的治疗选择,改善了整体和乳腺癌特异性生存率.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 辐射疗法 辐射疗法
背景情况:
- 越来越多的证据表明,乳房保护手术 (BCS) 与乳房切除术相比,可以提高存活率.
- 之前的研究集中在标准BCS上,但对瘤塑性BCS后的结果没有进行检查.
研究的目的:
- 为了比较BCS+放射治疗 (包括瘤BCS) 和乳腺切除术±初级侵入性乳腺癌放射治疗之间的生存结果.
主要方法:
- 从国家癌症登记处分析了2010-2019年间诊断的14182名患者.
- 使用卡普兰-梅尔和考克斯回归分析来评估总生存率和乳腺癌特定生存率,并对共变量进行调整.
主要成果:
- 与乳腺切除术±放射治疗相比,BCS +放射治疗显示出更高的10年整体存活率 (81.2%) 和乳腺癌特异性存活率 (93.3%) (OS:63.4-63.1%,BCSS:75.9-87.5%).
- 瘤塑性BCS + 放射治疗显示,与乳腺切除组相比,可比较的优异生存率 (10年OS: 86.1%,BCSS: 90.2%).
- 经过调整的分析证实BCS+放射治疗显著改善了乳腺切除术的生存率 (HRs从1.34到2.21不等).
结论:
- 标准和瘤BCS与放射治疗相结合,与乳腺切除术相比,具有明显更好的整体和乳腺癌特异性生存率.
- 这些发现提供了重要的证据,以指导乳腺癌患者的手术治疗决策.
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