自营养和装甲益生菌通过蛋启发封装
Sohyeon Park1,2, Sungwon Jung3, Geonhui Lee1,2
1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Advanced healthcare materials
|March 19, 2025
概括
一种新的受蛋启发的封装方法,即蛋中的益生菌 (PIE),可以有效地将益生菌口服. 这项技术增强了益生菌的生存和肠道殖民,促进了健康的肠道微生物群.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群对生理功能至关重要,其失调与肥胖,糖尿病和IBD等疾病有关.
- 口服益生菌的输送面临挑战,原因是胃肠道环境的稳定性不佳.
- 需要有效的输送系统来保持肠道微生物群的健康.
研究的目的:
- 开发一种创新的,以蛋为灵感的封装策略,以有效地提供口服益生菌.
- 评估使用PIE技术封装的益生菌的稳定性,功能性和生物可用性.
- 评估PIE作为维持肠道健康的实用平台的潜力.
主要方法:
- 开发了使用维和卵蛋白进行益生菌封装的益生菌在卵 (PIE) 技术.
- 在模拟的胃肠道中测试了PIE的稳定性和功能.
- 在口服后在小鼠模型中评估PIE生物可用性和肠道殖民化.
主要成果:
- 在模拟的GI条件下,PIE显著提高了益生菌的存活率和增殖率.
- 在营养缺乏的环境中,PIE有效地中和了活性氧物种 (ROS) 和持续的益生菌.
- 在小鼠中,PIE口服显示出出色的生物可用性和改善了肠道殖民.
结论:
- 以蛋为灵感的PIE技术为口服益生菌输送提供了一种强大而有效的方法.
- PIE增强了益生菌的稳定性和有效性,解决了当前传递系统的局限性.
- 这项技术在保持健康的肠道微生物组和预防相关疾病方面具有重大潜力.
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