评估患有喘的成年人的药物坚持程度及其对喘恶化的救援治疗的影响
Yi Ling Eileen Koh1, Kian Yong Kenny Chua2,3, Ding Xuan Ng1
1SingHealth Polyclinics, Research, Singapore, Singapore.
Frontiers in pharmacology
|March 19, 2025
概括
完全收集喘药物与更好的坚持和更少的恶化有关. 部分收集或不收集会增加急性喘事件的风险,强调持续使用药物的重要性,以改善患者的治疗结果.
科学领域:
- 肺部医学 肺部医学
- 行为科学 行为科学
- 健康 结果 研究 研究 结果
背景情况:
- 药物坚持 (MA) 对于控制喘和预防恶化至关重要.
- 传统的MA评估方法在现实世界临床实践中面临挑战.
- 行为科学为MA评估和恶化预测提供了新的方法.
研究的目的:
- 根据处方收集行为评估成年喘患者的药物坚持.
- 为了确定处方收集模式和随后的喘恶化之间的关系.
主要方法:
- 在新加坡 (2016-2023) 对13,482名患有喘的亚洲成年人的回顾性研究.
- 根据处方数据,患者被分类为完全收集 (FC),部分收集 (PC) 和没有收集 (NC) 组.
- 后勤回归用于分析MA,覆盖日数比例 (PDC) 和救援疗法 (RT) 的发生率.
主要成果:
- 72.9%的患者属于PC组,23.2%属于FC组,3.9%属于NC组.
- 与FC相比,PC和NC组在第二年出现RT (喘恶化) 的可能性明显更高.
- 较低的喘控制测试 (ACT) 分数与PC组有关.
结论:
- 服用完整处方喘药物的患者表现出更高的坚持.
- 完全遵守与经历急性喘恶化的可能性降低有关.
- 处方收集行为是预测喘恶化的有价值指标.
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