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干扰素调节因子3在小鼠中加剧了COVID-19的严重性

Wendy E Walker1,2, Luiz F Garcia2, Pedro M Palermo3

  • 1Department of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA.

Critical care explorations
|March 19, 2025
PubMed
概括

干扰素调节因子3 (IRF3) 通过促进有害炎症而不是病毒控制,加剧了严重的COVID-19. 缺少IRF3可以保护小鼠免受严重疾病的影响,这表明它在SARS-CoV-2感染中起着有害作用.

关键词:
在 COVID-19 疫情中,在K18-ACE2小鼠中.细胞因子 细胞因子人类 ангиотензин转化酶 2 转基因小鼠干扰素调节因子3 干扰素调节因子干扰子干扰子干扰子

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