增强的白血病预测使用混合殖民地和狮子优化用于基因选择和分类
Santhakumar D1, Gnanajeyaraman Rajaram1, Elankavi R2
1Department of Computer Science and Engineering, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu 602105, India.
MethodsX
|March 19, 2025
概括
一种新的混合殖民地优化-狮优化器 (ACO-ALO) 方法改善了微阵列数据的基因选择. 这种方法提高了癌症诊断的准确性和效率,优于传统方法.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 机器学习 机器学习
背景情况:
- 基因选择对于微阵列数据预处理至关重要,旨在识别关键基因以改善分类和降低成本.
- 遗传算法 (GA) 和最大相关性最小冗余 (MRMR) 等传统方法是常见的,但生物灵感算法提供了新的可能性.
- 殖民地优化 (ACO) 和狮子优化器 (ALO) 是有前途的,但单独使用时面临着过早融合等挑战.
研究的目的:
- 引入混合ACO-ALO方法,将两种算法的优势结合起来,以增强基因选择.
- 为了提高分类准确性,减少计算复杂性,并提高生物信息学应用中的分类器性能.
- 为了解决个别 ACO 和 ALO 算法在特征选择中的局限性.
主要方法:
- 结合殖民地优化 (ACO) 和狮子优化器 (ALO) 的混合方法被开发出来.
- 混合模型用于微阵列数据分析中的基因选择.
- 使用支持矢量机 (SVM) 来分类所选的最佳特征集.
主要成果:
- 混合ACO-ALO方法在白血病预测方面实现了93.94%的预测准确度.
- 与微阵列数据集的传统方法相比,提出的方法显示出更高的有效性和效率.
- 混合模型成功增强了功能选择,分类器性能,并降低了计算负载.
结论:
- 混合优化技术显示出在生物信息学中推进基因选择的巨大潜力.
- 开发的混合ACO-ALO方法通过改进的基因选择为准确的癌症诊断提供了强大的解决方案.
- 这项工作强调了集群智能算法用于复杂的生物数据分析的好处.
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