相关实验视频

Updated: May 21, 2025

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

三酶作为ST段升高心肌梗塞患者不良预后的生物标志物:一项前性队列研究

Pengxin Xie^1,2, Shuwan Xu^1,2, Xi Chen^1,2

¹Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, People's Republic of China.

Journal of inflammation research

|March 19, 2025

概括

提升的三酶水平,一个巨细胞激活生物标志物,预测主要不良心血管事件 (MACE) 在ST段升高心肌梗塞 (STEMI) 患者后初级穿皮冠状动脉干预 (PPCI). 酸酶是MACE的一个独立风险因素.

科学领域:

心脏病学心脏病学
免疫学免疫学免疫学
生物标志物生物标志物

背景情况:

ST段升高心肌梗塞 (STEMI) 涉及瘤细胞 (MCs) 的快速炎症.
在STEMI中,MC激活和不良心血管结果之间的联系尚未完全理解.
这项研究检查了三酶,一个巨细胞激活生物标志物,与主要不良心血管事件 (MACE) 有关.

研究的目的:

研究在接受初级穿皮冠状动脉干预 (PPCI) 的STEMI患者中血三酶水平和MACE之间的关联.
确定试酶是否在这个患者群体中是MACE的独立预测因子.
评估MACE的试酶的增量预测值.

主要方法:

对接受PPCI的514名STEMI患者进行前性研究.
用ELISA测量了PPCI后6小时的血三酶水平.
每6个月对MACE进行一次随访,随访时间中位数为13.28个月.

主要成果:

85名患者 (16.54%) 经历了MACE.
较高的三酶水平与MACE风险增加相关 (HR 2.60).
三酶是MACE的独立预测剂 (HR每单位增加1.56).
三酶在各种亚组中显示出预后价值,并改善了MACE预测 (AUC 0.763对比 0.702).

结论:

高酶水平是PPCI后STEMI患者MACE的显著预测因素.
酸酶作为一种有价值的生物标志物,用于识别高风险个体.
这些发现突显了巨细胞激活在STEMI预后中的作用.

关键词:

急性ST段升高心肌梗塞心肌梗塞主要的不良心血管事件.巨细胞巨细胞预后预后预后试酸酶的使用方法

更多相关视频

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

Peptide Identification Using Tandem Mass Spectrometry

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...