相关实验视频

Updated: May 21, 2025

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

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细胞内HIV-1 Tat调节器诱导DNA甲基化场景中的表观遗传变化

Andrea Rodríguez-Agustín1,2, Rubén Ayala-Suárez1, Francisco Díez-Fuertes3,4

  • 1AIDS and HIV Infection Group, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomédiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain.

Frontiers in immunology
|March 19, 2025
PubMed
概括

艾滋病毒Tat蛋白改变DNA甲基化,影响基因表达,并导致艾滋病毒感染者 (PWH) 的炎症和衰老. 阻止TAT可能会减少与艾滋病毒相关的并发症.

关键词:
通过DNA甲基化.艾滋病毒感染 艾滋病毒感染这就是Tat Tat Tat.表观遗传学是指表观遗传学.这是一种炎症炎症炎症炎症.

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Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

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Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Inheritance of Chromatin Structures

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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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