相关实验视频
Updated: May 21, 2025

08:23
Comet Assay as an Indirect Measure of Systemic Oxidative Stress
Published on: May 22, 2015
29.3K
在患有早期精神分裂症的患者中,认知障碍和氧化应激标志物之间的关系
Rongli An1, Xianli Zhang2, Xianglei Luo3
1Rongli An, Department of Psychiatry, The Eighth Hospital of Shijiazhuang, Shijiangzhuang 050080, Hebei, P.R. China.
Pakistan journal of medical sciences
|March 19, 2025
概括
早期精神分裂症的认知障碍与氧化压力有关. 观察到较低的超氧化物溶解酶 (SOD) 和谷氨过氧化酶 (GSH-Px) 和较高的同类半氨酸,催化酶,甲酸和氧化 (NO). SOD和甲与处理速度有负相关性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 早期精神分裂症 (EOS) 是一种严重的精神障碍,具有显著的认知缺陷.
- 氧化应激越来越多地与精神分裂症的病理生理学有关.
研究的目的:
- 研究EOS患者的认知障碍和特定的氧化应激标志物之间的关联.
主要方法:
- 一项回顾性研究,将42名EOS患者与42名健康对照人进行比较.
- 使用测量和治疗研究来改善精神分裂症认知 (MATRICS) 认知功能的认知功能评估共识认知电池 (MCCB).
- 测量了氧化应激标志物的血清水平,包括超氧化物脱酶 (SOD),马隆迪化物,谷氨过氧化酶 (GSH-Px),催化酶,同类蛋白和氧化 (NO).
主要成果:
- 与对照人群相比,EOS患者在MCCB评估的所有认知领域的得分明显较低.
- 在EOS患者中发现了高水平的homocysteine,catalase,malondialdehyde和氧化 (NO).
- 在EOS组中观察到超氧化物脱氧化酶 (SOD) 和谷氨过氧化酶 (GSH-Px) 的水平降低.
- 在SOD和甲水平和信息处理速度 (P <0.05) 之间发现了显著的负相关性.
结论:
- 早期精神分裂症的认知障碍与氧化应激标志物的不平衡有关.
- 特定的氧化应激标志物,特别是SOD和,与EOS患者的信息处理速度有负相关性.
更多相关视频
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
41
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
41
Negative and Cognitive Symptoms of Schizophrenia
39
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
39
Biological Causes of Schizophrenia
29
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
29
Aging
32
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
32
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
338
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
338
Psychoneuroimmunology: Diabetes and Cancer
20
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
20

