在基因决定的阿尔茨海默氏病的性别相关差异
Laura Del Hoyo Soriano1,2, Olivia Wagemann3, Alexandre Bejanin1,2
1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Barcelona, Spain.
Frontiers in aging neuroscience
|March 19, 2025
概括
在基因决定的阿尔茨海默病 (AD) 中,性别差异是微妙的,女性在晚年表现出更多的神经退行. 需要对性别特异因素和认知储备进行进一步的研究.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 呈现出复杂的基于性别的变异.
- 遗传决定的AD (例如,自体主导的AD,唐氏综合征相关的AD,APOE4同性) 呈现出独特的研究途径.
- 了解性别差异对于个性化的AD诊断和治疗至关重要.
研究的目的:
- 审查和综合现有的关于遗传决定性AD的性别差异的文献.
- 检查疾病透率,症状发作,临床进展和AT(N) 生物标志物轨迹的变化.
- 探索性别,APOE基因型和AD病变的相互作用.
主要方法:
- 关于基因决定AD的性别差异研究的综合文献综述.
- 专注于自体主导AD (ADAD),唐氏综合征相关的AD (DSAD) 和APOE4同性.
- 分析有关疾病透率,症状发作,临床进展和ATN标志物的数据.
主要成果:
- 在基因决定的AD中,性别差异通常在透,发病和AT (N) 轨迹方面是微妙的.
- 女性可能在晚期疾病阶段表现出增加的神经退行,具有相似的认知结果,这表明认知储备的潜在差异.
- 在DSAD中观察到APOE基因型和性别之间的复杂相互作用,这可能对ADAD产生潜在影响.
结论:
- 与零星的AD相比,基因决定的AD显示的性别差异较小,为不同的疾病机制提供了洞察力.
- 需要使用精细的方法,包括纵向设计和遵守性别指导方针,进行进一步的性别特定研究.
- 研究女性的差异性认知储备和复杂的性别-APOE相互作用对于推动AD研究至关重要.
关键词:
在阿尔茨海默病中的生物标志物轨迹 (粉样蛋白,蛋白和神经退行生物标志物)阿波利波蛋白 E 埃普西隆4 (APOE4) 同胞性同胞性自体主导性阿尔茨海默氏病 (ADAD)疾病透在阿尔茨海默氏症的疾病.唐氏综合征相关的阿尔茨海默氏病 (DS-AD)遗传决定性阿尔茨海默氏症是阿尔茨海默氏症.在阿尔茨海默氏病的性别差异.在阿尔茨海默病的症状发作阿尔茨海默病.更多相关视频
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
14.8K
10:02Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
Published on: May 28, 2017
26.6K
相关概念视频
01:26Alzheimer's Disease: Overview
405
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
405
01:28Human Genetics
506
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
506
01:22Alzheimer's Disease: Treatment
139
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
139
01:43Sex-linked Disorders
99.3K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
99.3K
01:19X-linked Traits
52.5K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
52.5K
01:29Biological Causes of Schizophrenia
29
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
29