高海拔对角膜内皮细胞的影响和白内障手术患者的预后:倾向性得分匹配分析

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概括

高海拔可能会增加白内障手术后的角膜六角细胞,但不会损害细胞密度. 在高海拔地区,术后视力较差,原因是手术时间较长,而不是角膜细胞变化.

科学领域:

眼科医生眼科眼科
高海拔的生理学高海拔的生理学

背景情况:

白内障手术的结果可能会受到环境因素的影响.
高海拔带来了独特的生理挑战,原因是氧气供应减少 (低氧).

研究的目的:

为了研究高海拔对角膜内皮细胞 (CECs) 在白内障手术后的影响.
为了比较视力敏度 (VA) 和手术结果,在海拔高处接受白内障手术的患者与海平面相比.

主要方法:

对265名高原患者 (平均海拔3000米) 和524名接受白内障手术的平原患者进行了回顾性分析.
倾向性得分匹配 (PSM) 用于1:1患者匹配.
角膜内皮细胞密度 (ECD),变化系数 (CV),六角细胞比率 (HEX),手术持续时间和术前/术后VA的比较.

主要成果:

匹配的队列: 223 对. 平原期患者的HEX显著更高 (61.95%与44.91%,P<0.001).
两组之间ECD或CV没有显著差异 (P>0.1).
平原患者的术前/术后VA较低 (P<0.001) 和手术持续时间较长 (27.06分 vs 16.03分,P<0.001). 手术后的VA与手术前的VA和手术持续时间相关,而不是CEC参数.

结论:

高海拔的低氧环境不会增加CEC亡,可能会诱导补偿性功能增加.
在白内障手术后平原患者的视力较差的结果与CEC功能没有直接关系,而是与更长的手术持续时间等因素有关.

关键词:

白内障手术是什么?白内障手术是什么?角膜内皮细胞角膜内皮细胞缺氧缺氧是指缺氧的情况.高原高原是一个高原.倾向性得分匹配的比分匹配

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