用于瞳孔扩张的多皮卡米德复合剂眼滴的不同给药方案,用于患有暗虹膜的儿童:一项随机临床试验
Xu Xu1, Lian-Xin Zhang1, Jing-Jing Jiang1
1National Center for Children's Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
International journal of ophthalmology
|March 19, 2025
概括
增加复合热胺眼滴 (CTE) 的频率和间隔显著提高了儿童的瞳孔扩张. 与三次应用方案相比,每隔五分钟的四次应用方案产生了优异的水分效应.
科学领域:
- 眼科医生 眼科 眼科
- 儿科眼科护理 儿科眼科护理
- 药理学 药理学是指药理学的学科.
背景情况:
- 准确的瞳孔扩张对于儿科眼科检查至关重要.
- 复合型热胺眼液 (CTE) 常用于肌病.
- 优化CTE管理方案可以提高考试效率.
研究的目的:
- 为了比较不同化合物热皮卡米德眼滴 (CTE) 给药方案在患有黑色虹膜的儿童中瞳孔扩张的疗效.
- 为了确定CTE应用的最佳频率和间隔.
主要方法:
- 一个前性的,随机的,比较的干预研究.
- 两组儿童接受了CTE:第一组 (3次应用,3分钟间隔),第二组 (4次应用,5分钟间隔).
- 瞳孔直径和瞳孔光反射在基线,30分钟和60分钟后被测量.
主要成果:
- 与第一组相比,第二组在30分钟和60分钟时显示出明显更大的瞳孔膨胀变化 (P<0.01).
- 第二组的水分效应是第一组的1.25倍.
- 在第二组的儿童中,更高的百分比达到瞳孔大小≥6.5毫米和非反应性瞳孔.
结论:
- 增加复合物热皮卡米德眼滴的频率和间隔可以增强眼液效应.
- 在儿童中,以5分钟的间隔进行4次应用的疗法对瞳孔扩张更有效.
- 年龄正面相关于瞳孔尺寸变化在mydriasis.
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