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在接受抗血管内皮生长因子治疗的视网膜静脉封闭的年轻患者的血清学参数

Tong-Tong Niu¹, Yun Xiao¹, Wen-Juan Lyu¹

¹Department of Ophthalmology, Xinjiang 474 Hospital, Urumchi 830000, Xinjiang Uygur Autonomous Region, China.

International journal of ophthalmology

|March 19, 2025

概括

血小板与淋巴细胞比率 (PLR) 和全身免疫炎症指数 (SII) 的升高预测,接受内内康贝塞普注射 (IVC) 治疗的视网膜静脉封闭 (RVO) 的年轻患者的治疗结果会更好.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
炎症标志物炎症标志物

背景情况:

视网膜静脉封闭 (RVO) 影响年轻人,导致黄斑 (RVO-ME).
内康伯塞普注射 (IVC) 是对RVO-ME的治疗方法.
年轻RVO患者治疗成功的预后因素需要进一步调查.

研究的目的:

评估治疗前血清炎症标志物与IVC在年轻RVO-ME患者的疗效之间的关联.
为了确定成功IVC治疗结果的预测血清学参数.

主要方法:

分析了使用IVC治疗的100名年轻RVO-ME患者的队列.
患者被分为有效组 (≥2行视敏度改善,解决) 和无效组.
评估了治疗前的血清参数,包括白细胞计数,中性粒细胞,淋巴细胞,单细胞计数,平均血小板体积和衍生比率 (NLR,PLR,SII,SIRI).

主要成果:

有效组在IVC后的最佳校正视敏度 (BCVA) 和中央黄斑厚度 (CMT) 中显著改善 (P<0.001).
在有效组与无效组相比,在治疗前观察到更高的血小板与淋巴细胞比率 (PLR) 和全身免疫炎症指数 (SII) (P<0.05).
这些协会在中央RVO (CRVO) 和分支RVO (BRVO) 子组中保持一致.

结论:

在接受IVC的年轻RVO-ME患者中,治疗前PLR和SII水平的升高是有利结果的显著预测因素.
这些炎症标志物可以帮助预测治疗反应,并指导临床管理策略.

关键词:

抗血管内皮生长因子的抗血管内皮生长因子中性粒细胞与淋巴细胞的比率.视网膜静脉闭塞视网膜静脉闭塞系统性免疫-炎症指数

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