功能障碍与对糖尿病黄斑的静脉内康伯塞普治疗的临床反应相关
Wei Wu1, Hui-Dong Liu2, Xue Xiao2
1Department of Ophthalmology, GuangZhou Red Cross Hospital of Jinan University, Guangzhou 510000, Guangdong Province, China.
International journal of ophthalmology
|March 19, 2025
概括
功能障碍会对糖尿病黄斑的治疗有效性产生负面影响,使用内康贝塞普特注射. 功能受损是减少对这种治疗的临床反应的危险因素.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 内康伯塞普注射 (IVC) 是对DME的治疗方法,但其疗效可能受到系统因素的影响.
- 功能障碍是糖尿病的常见并发症,可能会影响治疗结果.
研究的目的:
- 调查功能障碍对糖尿病黄斑胀 (DME) 患者内内康贝塞普注射 (IVC) 临床反应的影响.
主要方法:
- 对100名用IVC治疗的DME患者进行了回顾性研究.
- 患者被分为正常功能,功能受损和功能不全组,根据估计的淋巴球透率 (eGFR).
- 评估了最佳校正视敏度 (BCVA) 和中央子场黄斑厚度 (CST) 的评估变化.
主要成果:
- 在所有组中观察到BCVA的整体改善和CST的显著减少.
- 具有正常功能的患者基线血红蛋白较高,基线CST较薄.
- 更高的eGFR,血红蛋白和更厚的基线CST与更好的IVC解剖反应 (黄斑回归) 有关.
结论:
- 功能障碍被确定为与 IVC 对 DME 的疗效相关的风险因素.
- 这些发现表明,在评估DME患者对IVC的治疗反应时,应该考虑功能状态.
相关概念视频
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...