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揭示微型和纳米塑料在胚胎发育中的影响

Sanjay R Nair¹, Muhammad Nihad¹, Sudheer Shenoy P¹

¹Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Deralakatte, Mangalore, Karnataka 575018, India.

Toxicology reports

|March 19, 2025

概括

微型和纳米塑料会损害胚胎发育和细胞功能. 3D胚胎体模型为研究这些毒性影响和发育影响提供了一个有前途的体外平台.

科学领域:

环境科学环境科学
发展生物学发展生物学
毒理学毒理学毒理学

背景情况:

塑料污染会产生微型塑料和纳米塑料,这些塑料会在生态系统中积聚并影响生物.
关于微/纳米塑料暴露对生殖健康和早期发育的影响的数据有限.
这些粒子可以在发育中的胚胎中诱导神经毒性和炎症.

研究的目的:

审查3D体外模型对胚胎毒性研究的重要性.
评估微塑料来源,表面化学和细胞毒性影响.
探索微/纳米塑料在胚胎多能性和分化中的作用.

主要方法:

对现有的关于微塑料生成,表征和毒性的文献进行审查.
讨论来自多能干细胞的3D胚胎体 (EB) 模型的实用性.
对人类胚胎研究的伦理考虑和替代研究模型的分析.

主要成果:

3D EB模型有效地模仿人类胚胎发育的毒性测试.
微型和纳米塑料在发育过程中对细胞和代谢功能构成风险.
关于微塑料对多能性和胃化的影响的综合数据仍然很少.

结论:

3D体外模型,特别是EBs,对于评估微塑料胚胎毒性至关重要.
需要进一步的研究才能充分理解微/纳米塑料对生殖健康和发育的影响.
了解塑料颗粒的来源和化学成分对于风险评估至关重要.

关键词:

在体外3D模型.细胞系谱规范细胞系谱规范胚胎体是一个胚胎体.胚胎毒性胚胎毒性微型和纳米塑料的微型和纳米塑料多能干细胞是多能干细胞.

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