多omics分析揭示了可转移元素在牲畜基因组中的关键cis调控作用
Chao Wang1,2,3, Bowen Lei1,2,3, Yongzhou Bao1,3,4,5
1Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, P.R. China.
iScience
|March 19, 2025
概括
可移植元素 (TE) 显著影响牲畜中的遗传变异. 这项研究揭示了它们的组织特异性调节作用,并为了解猪,牛和中的TE基因网络开发了一个框架.
科学领域:
- 基因组学和生物信息学
- 分子生物学分子生物学
- 动物遗传学 动物遗传学
背景情况:
- 可移植元素 (TE) 是可移动的遗传序列,有助于基因组的进化和变异.
- 它们在养动物中的功能作用,特别是在基因调节方面,尚未完全理解.
- 了解TE的影响对于畜牧业改进和遗传研究至关重要.
研究的目的:
- 在猪,牛和基因组中全面注释可移植元素 (TE).
- 调查TE对cis调节元件 (CREs) 和跨组织基因表达的影响.
- 开发一个计算框架来发现TE-介导的基因调节网络 (TE-GRNs).
主要方法:
- 在Sus scrofa,Bos taurus和Gallus gallus中对TE类型,年龄和分布的全基因组注释.
- 整合转录基因和表观基因数据来分析TE表达和染色质可访问性.
- 开发一个计算框架来识别TE-GRNs.
主要成果:
- 确定了 TE 丰度,放大和活动的特定物种模式.
- 发现组织特异性TE表达和染色质可访问性可以调节组织特异性的生物过程.
- 该研究构建了一个TE表达图谱和一个用于TE-GRN分析的计算框架.
结论:
- 可转移的元素在动物组织特异性基因表达的调节中起着关键作用.
- 开发的计算框架为研究TE-GRNs提供了一个强大的方法.
- 这些发现为养动物中TEs的功能意义提供了有价值的见解.
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