心血管和代谢结果与中度至重度的亚托皮性皮肤炎相关:系统性审查和元分析
Suvijak Untaaveesup1, Thipsukon Amnartpanich2, Noraworn Jirattikanwong3,4
1Chao Khun Paiboon Hospital, Kanchanaburi, Thailand.
患有中度至重度亚托皮性皮炎 (AD) 的人面临心血管和代谢疾病的风险增加. 早期风险评估对于在阿尔茨海默病患者中管理这些疾病至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 心脏病学 心脏病学
- 代谢医学是一种代谢医学.
背景情况:
- 慢性系统性炎症在中度至重度的亚托皮性皮炎 (AD) 中可能会增加对代谢和心血管疾病的易感性.
- 现有证据将AD与这些疾病联系起来是有限的,需要进一步调查.
研究的目的:
- 系统地评估中度至重度AD与代谢和心血管结果之间的关联.
- 量化与普通人群相比,中度至重度AD患者的各种健康结果的风险.
主要方法:
- 在主要数据库 (PubMed,Scopus,EMBASE,Cochrane) 进行了系统的文献搜索,以寻找基于人口的研究.
- 使用随机效应模型对11项纳入研究的数据进行了元分析 (405,170名AD患者与4,591,478名对照).
- 对于每个结果,报告了聚合的几率比率 (OR) 和证据确定性.
主要成果:
- 中度至重度的AD与心肌梗塞 (OR1.33),心痛 (OR1.33),心力衰竭 (OR1.56),中风 (OR1.45),高血压 (OR1.38),失脂症 (OR1.27) 和代谢综合征 (OR1.24) 的风险显著增加有关.
- 没有观察到心血管死亡 (OR 1.81) 或糖尿病 (OR 1.24) 的风险显著增加.
- 大多数关联的证据确定性被评为非常低,在研究中发现了很高的异质性.
结论:
- 在中度至重度的AD和对代谢和心血管疾病的易感性增加之间存在适度但显著的关联.
- 建议对中度至重度AD患者进行常规心血管和代谢风险评估,以促进早期干预.
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