在实体器官或骨髓移植后入住重症监护室的患者:回顾性队列研究
Ana Vujaklija Brajkovic1,2, Iva Kosuta1, Lucija Batur1
1Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb 10000, Croatia.
World journal of transplantation
|March 19, 2025
概括
固体器官移植 (SOT) 和造血干细胞移植 (HSCT) 患者因败血症入院ICU的死亡率很高. 早期识别和治疗对于改善结果至关重要,特别是在HSCT接受者中.
科学领域:
- 关键护理医学 关键护理医学
- 移植免疫学 移植免疫学
- 传染性疾病 传染性疾病
背景情况:
- 固体器官移植 (SOT) 和造血干细胞移植 (HSCT) 显著提高了患者的生存率和生活质量.
- 这些程序对于治疗恶性疾病,免疫学疾病和代谢疾病至关重要.
- 然而,移植后的患者仍然容易患上需要重症监护的严重疾病.
研究的目的:
- 确定在SOT和HSCT患者的重症监护病房 (ICU) 入院的主要原因.
- 分析这些重症移植受体的治疗结果和生存率.
- 确定与医疗ICU环境中的生存相关的因素.
主要方法:
- 进行了一项回顾性,单中心的流行病学研究.
- 从2018年1月1日至2023年12月31日期间入院医疗ICU的患者收集了数据.
- 分析包括患者人口统计,并发症,入院原因,干预措施和生存率.
主要成果:
- 败血症和败血性休克是91名SOT和HSCT患者 (69.2%的HSCT) 进入ICU的主要原因.
- 与SOT患者 (57%) 相比,HSCT患者 (12.7%) 的ICU存活率明显较低.
- 机械通风和血管压缩剂治疗与生存相关,而脏置换疗法则没有.
结论:
- 败血症和败血性休克是常见的,高死亡率导致SOT和HSCT后ICU入院的原因.
- 尽管重症监护的进步,耐火性败血症和多器官衰竭在这个人群中带来了极高的死亡率.
- 及时的ICU入院和早期识别危急疾病可能会改善结果,特别是在HSCT患者身上.
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