整个历史上的巨人主义和暴虐
Maša Malenica1, Tena Trbojević1, Stjepan Herceg1
1Division of Pediatric Neurology, Department of Pediatrics, Sestre milosrdnice University Hospital Center, EpiCARE center, Zagreb, Croatia.
Acta clinica Croatica
|March 19, 2025
概括
巨人症和巨症,增长激素过量的情况,已经从神话演变为医学理解. 尽管在诊断和治疗方面取得了进展,但手术治疗仍然是最佳的.
科学领域:
- 内分泌学 在内分泌学.
- 医学史 医学史 医学史
- 神经外科 神经外科
背景情况:
- 在医学认可之前,巨人主义和壮症在历史上被视为神话般的疾病.
- 早期的医学描述可以追溯到16世纪,在19世纪正式命名.
- 神经外科医生在20世纪初开始参与其中,将垂体腺瘤与这些疾病联系起来.
研究的目的:
- 追踪理解巨型症和巨症的历史进展.
- 突出诊断和治疗的关键里程碑.
- 强调当前最佳的治疗策略.
主要方法:
- 医学文献和临床观察的历史综述.
- 追踪诊断工具的演变以及对生长激素 (GH) 和类似胰岛素的生长因子 (IGF-I) 的理解.
- 分析治疗方式,包括手术,放射治疗和药物治疗.
主要成果:
- 认知从神话描述演变为科学理解,确定生长激素 (GH) 过分分泌为原因.
- 自20世纪初以来,手术干预,特别是对垂体腺瘤的跨形手术,一直是20世纪初以来的基石.
- 药物治疗,如多巴胺激动剂,索马托斯塔丁类似物和GH受体阻断剂,是在1970年后引入的.
结论:
- 尽管医学科学和内分泌学取得了重大进展,但手术治疗仍然是对巨症和巨症的首要和最有效的治疗方法.
- 基础科学和临床内分泌学的持续进步对于改善病原体的理解,诊断和治疗至关重要.
- 历史上的旅程强调了医学和科学在理解和管理这些疾病方面取得的巨大进步.
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