在高血压前的个体中调查肠道微生物群概况,这些个体表现出液湿度结构
Ning Yu1,2,3, Yaotang Yang4, Guangyun Wang5
1School of Public Health, Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Frontiers in cellular and infection microbiology
|March 19, 2025
概括
肠道微生物组的差异区分高血压前期与液湿度构成 (PDC) 与非PDC个体. 这些发现为早期检测和高血压前的有针对性的干预提供了潜在的生物标志物.
科学领域:
- 微生物组研究的研究.
- 在高血压的高血压.
- 传统中国医药 传统中国医药
背景情况:
- 前高血压是高血压的临床前阶段,通常是无症状的.
- 液湿度构成 (PDC) 在高血压前是普遍存在的.
- 肠道失调与高血压有关,但其在高血压前PDC中的作用尚不清楚.
研究的目的:
- 为了研究高血压前患者的肠道微生物组特征,这些患者有湿体构成 (PDC).
- 识别特定的细菌标记物,将高血压前PDC与其他群体区分开来.
- 评估这些标记物的诊断潜力.
主要方法:
- 来自三组便样本的16S rRNA基因测序:高血压前PDCs,高血压前非PDCs (NPDCs) 和健康对照 (BC).
- 随机森林分类,以识别高血压前PDC组中的特定细菌.
- 接收器操作特征 (ROC) 分析以确定诊断效率 (AUC).
主要成果:
- 在PDC群中,细菌群水平上减少了Bacteroidetes的丰富性.
- 在PDC和NPDC组之间,特定属 (例如,Parabacteroides,Corynebacterium) 的相对丰度存在显著差异.
- 对于已识别的细菌标记物,ROC分析表明了潜在的诊断值 (AUC 0.653-0.706).
结论:
- 肠道微生物组概况可以区分患有PDC的高血压前个体与没有的个体.
- 已识别的细菌属代表了高血压前PDCs的潜在生物标志物.
- 这些发现可以指导新的高血压前期预防和治疗策略.
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