同时发生的饮食障碍和心理创伤的生物治疗方法:系统性审查
Ella van Beers1,2, Irene de Vries1, Caroline Planting3,4
1Novarum Center for Eating Disorders & Obesity, Amstelveen, Netherlands.
Frontiers in psychiatry
|March 19, 2025
概括
生物治疗对患有饮食障碍和心理创伤的人来说是有前途的,尽管需要更多的研究. 不良事件很常见,数据限制影响了研究结果.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 许多患有饮食障碍的人报告说,他们有童年虐待或创伤的历史.
- 同时出现的饮食障碍和心理创伤很普遍,但对联合治疗的研究仍然有限.
- 现有的文献缺乏对这种双重诊断人群的生物治疗有效性和安全性的全面综合.
研究的目的:
- 系统地审查和综合现有关于生物治疗治疗同时发生的饮食障碍和心理创伤的研究.
- 评估这些生物干预措施在目标人群中的安全性.
- 确定当前研究中的差距,并提出未来的研究方向.
主要方法:
- 在主要数据库 (PubMed,Embase,PsycINFO,Web of Science,Scopus,Cochrane Central) 进行了系统的文献搜索,遵循先验协议.
- 纳入标准侧重于报告生物干预和至少一个饮食障碍或心理创伤结果的研究.
- 包括的研究的质量评估是使用非随机研究或干预 (ROBINS-I) 中偏差风险工具进行的.
主要成果:
- 十一篇文章符合纳入标准,检查了诸如重用药物,胺,重复性跨磁刺激 (rTMS),深度大脑刺激,电疗法 (ECT),MDMA和神经反等治疗方法.
- 所有研究都表明,饮食障碍或创伤病理有所改善,重复性跨磁刺激 (rTMS) 和MDMA显示出最强效应.
- 在各个干预措施中报告了常见的不良事件,缺失的数据/选择性报告限制了研究结果的解释性.
结论:
- 尽管在饮食障碍患者中心理创伤的患病率很高,但对于这种并发症的治疗方法很少有评估.
- 生物治疗,包括rTMS和MDMA,对于同时出现饮食障碍和心理创伤的人来说,证明了潜在的益处.
- 需要进一步的研究来调查这种复杂的患者群体的生物干预措施的有效性和安全性.
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