Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tissue Transplantation01:24

Tissue Transplantation

320
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
320
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

45
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
45
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

268
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
268

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Response to the Letter to the Editor Entitled "A Missing Genomic Dimension: The Small but Central Mitochondrial Genome in Diabetic Kidney Disease Genetics".

Kidney international reports·2026
Same author

A Novel Approach to Interrogating Whole Genome Sequencing Data to Optimise Clinical Utility.

Molecular genetics & genomic medicine·2026
Same author

OPTN/SRTR 2024 Annual Data Report: Deceased Organ Donation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Apolipoprotein E (APOE) genotyping in the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA).

BMC research notes·2026
Same author

Detecting comorbidity patterns in rare disease patients with machine learning.

Frontiers in epidemiology·2026
Same author

Genetic array data from the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA).

Research square·2026
Same journal

Cold ischemia time exceeding 12 hours is a risk factor for delayed graft function and increased mortality in kidney transplant recipients within the eurotransplant senior program.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Impact of pre-transplantation exposure to immunosuppressive agents on lung transplant outcomes in interstitial lung disease.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Delayed graft function and long-term outcomes after deceased donor kidney transplantation: insights from mate-kidney analysis.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Regulatory approach to manipulated organs in Europe: preserving human organs as non-commercial goods.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Can european law keep pace with biomedical innovation? The reinvention of transplantation regulation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same journal

Sex-related differences in survival based on [<sup>18</sup>F]FDG PET/CT metabolic tumor volume after liver transplantation for colorectal liver metastases.

Transplant international : official journal of the European Society for Organ Transplantation·2026
查看所有相关文章

相关实验视频

Updated: May 21, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.2K

捐赠者和接受者多基因风险评分 影响脏移植 功能

Kane E Collins1,2,3, Edmund Gilbert1,2, Vincent Mauduit4

  • 1School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

Transplant international : official journal of the European Society for Organ Transplantation
|March 19, 2025
PubMed
概括
此摘要是机器生成的。

对于功能特征的捐赠者和接受者遗传风险评分显示,在移植后的早期,与移植移植的功能有着很小,但具有统计学意义的关联. 然而,这种遗传影响目前太小,无法在预测移植成功时有临床应用.

关键词:
美国GFRGFR接种器的功能植入物生存率 植入物生存率多变量模型是多变量模型.多基因风险得分的多基因风险得分.

更多相关视频

Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.1K
Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
09:04

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry

Published on: April 19, 2017

13.4K

相关实验视频

Last Updated: May 21, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.2K
Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.1K
Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
09:04

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry

Published on: April 19, 2017

13.4K

科学领域:

  • 腎臟病學 (nephrology) 是一種醫學專業.
  • 遗传学 遗传学 是一个
  • 移植免疫学 移植免疫学

背景情况:

  • 移植结果受到各种因素的影响,但仍然存在显著的不明原因变化.
  • 捐赠者和接受者的遗传倾向可能会导致移植功能的这种变化.

研究的目的:

  • 调查多基因风险评分 (PRS) 与功能相关的特征在捐赠者和接受者和移植结果之间的关联.
  • 确定PRS是否解释了移植后移植功能中任何无法解释的变异性.

主要方法:

  • 组建了一个由6060个活着和已故的脏捐赠者-接受者对组成的队列.
  • 对捐赠者和接受者的功能相关特征计算的PRS.
  • 评估了PRS与受体估计的球过率 (eGFR) 在移植后1年和5年和移植失败后的关联.

主要成果:

  • 捐赠者的高血压PRS,eGFR PRS和内动脉瘤PRS,以及接受者的eGFR PRS,与1年移植后的eGFR有关.
  • 除了临床因素之外,PRS在移植后1年和5年间累计解释了额外1%的eGFR变化.
  • 在PRS和长期移植存活之间没有发现显著的关联.

结论:

  • 捐赠者和接受者的PRS显示出与早期移植功能 (移植后1年和5年的eGFR) 有着微小但统计学上显著的关联.
  • 目前PRS对脏移植结果的预测能力有限,不太可能具有即时的临床效用.
  • 需要进一步的研究来提高PRS的性能,以便在移植中潜在的临床应用.