一个患有呼吸道共囊病毒和Streptococcus pyogenes联合感染的儿童的严重肺炎溢出
Hikaru Sugita1, Hiroki Miura1, Kazuhiro Horiba2
1Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, JPN.
呼吸道同胞性病毒 (RSV) 在儿童中可以先发于严重的A型链球菌感染. 尽管使用了抗生素,但病情迅速恶化,这突显了侵入性GAS的诊断挑战.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 呼吸道同胞性病毒 (RSV) 是一个常见的儿童疾病.
- 细菌共感染可以使病毒性呼吸道感染复杂化.
- 侵袭性A组链球菌 (GAS) 感染可能导致严重的后果.
研究的目的:
- 为了调查一个严重的入侵性A型链球菌 (GAS) 感染的病例,该病例是在呼吸道同胞病毒 (RSV) 之后发生的.
- 突出共感染的诊断挑战.
- 为了强调即使在健康的孩子身上也可能发生的快速恶化.
主要方法:
- 一个儿科患者的临床病例审查.
- 对抗生素治疗反应的分析.
- 下一代测序 (NGS) 在腹液上的诊断用途.
主要成果:
- 一个患有RSV的四岁男孩经历了快速恶化.
- 肺流需要重症监护和手术除.
- 胸腔液培养是负的,但NGS确定了A组链球菌 (GAS).
结论:
- RSV 感染可以先于具有迅速进展的侵入性 GAS 疾病.
- 诊断GAS共感染可能是具有挑战性的,特别是负的初始培养.
- 下一代测序有助于在困难的情况下识别病原体.
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