神经可塑性和疼痛感知:探索关节疾病的复杂性
1Physiology, All India Institute of Medical Sciences, Raebareli, Raebareli, IND.
Cureus
|March 19, 2025
概括
部疾病 (TMD) 涉及复杂的疼痛机制. 了解外周和中枢神经系统的神经可塑性是开发有效治疗TMD疼痛的关键.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 口腔和牙面部外科手术
背景情况:
- 关节疾病 (TMD) 是影响关节 (TMJ) 和肌的常见疾病.
- TMDs表现为疼痛,有限的运动和关节声音,源于多因素的原因.
- 背后的神经生理机制TMD疼痛感知是复杂的,涉及到外周和中枢神经系统的过程.
研究的目的:
- 本综述探讨了TMD患者疼痛的神经生理学的基础.
- 它侧重于外周和中心敏感性和神经可塑性在慢性TMD疼痛中的作用.
- 目的是阐明这些机制,以指导向治疗的开发.
主要方法:
- 关于TMD的神经生理学和疼痛机制的当前文献的综述.
- 分析周边过程,包括感觉受体激活和敏感化.
- 检查中心过程,如中心敏感化,神经可塑性和神经免疫相互作用.
主要成果:
- 周围机制涉及TMJ nociceptor激活和通过炎症介导体敏感化.
- 中枢敏感性,以神经可塑性变化为特征,如上风和LTP,增强中枢神经系统的疼痛感知.
- 神经可塑性,包括突触变化和大脑连接变化,在慢性TMD疼痛的发展中至关重要.
结论:
- 了解外围和中心疼痛机制,包括神经可塑性和神经免疫相互作用,对于TMD管理至关重要.
- 针对TRP通道和神经免疫通路的新兴疗法提供了有希望的途径.
- 针对外围和中央疼痛发生器的多方面的治疗方法对于有效的TMD疼痛控制至关重要.
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