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液-液相分离驱动癌症中的免疫信号传导:一项从1992年到2024年进行的文献计和可视化研究

Yanhong Pei¹, Haijie Liang¹, Yu Guo¹

¹Department of Bone Tumor, Peking University People's Hospital, Beijing, China.

Frontiers in oncology

|March 19, 2025

概括

本文献分析绘制了癌症免疫信号中的液态-液态相分离 (LLPS) 的日益增长领域. 研究突出了关键的途径和机制,为未来的癌症免疫疗法开发提供了见解.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
免疫学免疫学免疫学

背景情况:

液-液相分离 (LLPS) 对于细胞功能至关重要.
关于LLPS在癌症免疫信号传递中的有限的文献计量分析.
这项研究解决了在这个领域缺乏全面研究的问题.

研究的目的:

对癌症免疫信号通路的LLPS研究进行文献计量评估.
探索这个跨学科领域的当前景观和未来方向.

主要方法:

1992-2024年出版物的定量和定性分析.
数据来源于科学网络核心集合的数据.
利用多重分析软件进行全面的审查.

主要成果:

中国和美国在出版物方面处于领先地位;主要期刊包括"国际分子科学杂志"和"蛋白质学".
出版率显示,从2020年至2024年有显著的上升趋势.
常见的关键词:表达,分离,激活,免疫疗法,机制;通路:TCR,BCR,cGAS-STING,RIG-1,NF-κB.

结论:

这是LLPS在癌症免疫转导中的第一个整合性地图.
该领域还处于芽阶段,但显示出了解癌症发展的潜力.
LLPS和免疫信号的空间框架可以提高癌症免疫治疗的有效性.

关键词:

在CiteSpace中使用CiteSpace.圣经计量资料 (Bibliometric bibliometric bibliometric) 是指参考书目中的资料.癌症癌症癌症癌症癌症免疫传导免疫传导液态液态相分离 (LLPS) 的方法

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