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在接受辅助免疫治疗的头部和部癌症患者中,部剖析和生存率

Aman M Patel¹, Afash Haleem¹, Paul T Cowan¹

¹Department of Otolaryngology-Head and Neck Surgery Rutgers New Jersey Medical School Newark USA.

Laryngoscope investigative otolaryngology

|March 19, 2025

概括

在接受免疫治疗的头癌 (HNC) 患者中,大约一半进行了部剖析 (ND). 这项研究发现,在接受免疫治疗的HNC患者中,ND并没有恶化整体存活率 (OS).

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
免疫治疗是一种免疫疗法.

背景情况:

在接受免疫治疗的头癌 (HNC) 患者中,部剖析 (ND) 是一个有争议的问题,因为淋巴结对于免疫反应至关重要.
本研究研究了ND的利用及其对接受辅助免疫治疗的HNC患者整体存活率 (OS) 的影响.

研究的目的:

在接受辅助免疫治疗的头癌 (HNC) 患者中研究部解剖 (ND) 的利用.
为了确定ND是否会影响这一患者群体的整体存活率 (OS).

主要方法:

对2013-2018年国家癌症数据库的回顾性审查,对HNC患者进行治疗意图的手术并接受辅助免疫疗法.
使用多变量后勤和考克斯回归模型,根据患者人口统计,临床病理特征和治疗方式进行调整.

主要成果:

在1335名患者中,679人 (50.9%) 接受了ND. 与较高的ND几率相关的因素包括学术治疗设施和高级临床T和N阶段 (cT4,cN1-3).
在Kaplan-Meier分析中,接受ND的患者的生存状况较差 (49.4%对61.5%),但这种关联在多变量考克斯回归 (aHR 1.00,p=0.968) 中没有显著意义.
与单独免疫疗法相比,辅助放射治疗 (aHR 0.64) 和化疗放射治疗 (aHR 0.56) 与改善的生存状况有关.

结论:

在接受辅助免疫治疗的HNC患者中,大约51%的患者使用了部剖析 (ND).
在这个队列中,ND与更糟糕的整体存活率 (OS) 没有关联,这可能是由于先进节点分类 (pN1-3) 的高率.

关键词:

国家癌症数据库.头部和部癌症头部和部癌症免疫疗法免疫疗法辐射疗法辐射疗法幸存率幸存率生存率

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