相关实验视频
Updated: May 21, 2025
06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
23.2K
上腺和宫外库希综合征的奥西洛德罗斯塔特治疗:临床研究与病例介绍的整合
Maria Fleseriu1, Richard J Auchus2,3, Irina Bancos4
1Pituitary Center, Departments of Medicine and Neurological Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
Journal of the Endocrine Society
|March 19, 2025
概括
奥西洛德罗斯塔特为库希综合征提供了有效的医疗治疗,包括宫外或上腺原因. 个性化剂量和监测是优化治疗结果和控制库辛综合征患者副作用的关键.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 库希综合征有不同的病因,包括垂体腺瘤,宫外源和上腺瘤.
- 虽然手术是首要的,但对于非手术候选人或非响应者而言,医疗治疗至关重要.
- 作为11β-基酶抑制剂的奥西洛德罗斯塔特在库辛病中显示出有效性,在其他形式中越来越多地使用.
研究的目的:
- 讨论在子宫外或上腺库辛综合征中对奥西洛德罗斯塔特的实际管理考虑.
- 审查已公布的关于在这些特定患者群体中使用osilodrostat的数据.
- 突出库辛综合征管理的个性化治疗方法.
主要方法:
- 关于异卵巢和上腺库辛综合征中奥西洛德罗斯塔特的已发表数据的审查.
- 讨论说明性的案例研究.
- 对治疗考虑因素的分析,包括剂量,定位和不良事件监测.
主要成果:
- 奥西洛德罗斯塔特在降低跨库辛综合征病因的皮质醇水平方面表现出有效性.
- 个性化治疗策略对于优化治疗效益至关重要.
- 需要仔细监测诸如低皮质醇和QT延长等不良事件.
结论:
- 奥西洛德罗斯塔特是一种可行的医疗选择,用于宫外和上腺库辛综合征.
- 个性化管理,考虑到疾病严重程度和患者因素,最大限度地提高了osilodrostat的益处.
- 有效的皮质醇控制与osilodrostat可以改善并发症和生活质量.
相关概念视频
01:27Adrenal Gland Disorders
1.3K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.3K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
92
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
92
01:17Drugs for Treatment of Diarrhea-Predominant IBS
131
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
131
01:29Chronic Pancreatitis II: Collaborative Care
52
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
52
01:21Drugs for Treatment of Constipation-Predominant IBS
124
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
124
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
183
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
183