硫甲/基希夫基联体的金属复合物:合成,表征,DFT计算和抗菌活动
1Department of Pharmaceutical Chemistry, Hamidiye Faculty of Pharmacy, University of Health Sciences, İstanbul, Turkiye.
Turkish journal of biology = Turk biyoloji dergisi
|March 19, 2025
概括
新型希夫基金属复合物显示出作为抗菌剂的前景. 铜和复合物分别表现出显著的抗真菌和抗菌活性,提供了对抗性细菌的潜在新疗法.
科学领域:
- 协调化学 协调化学
- 药用化学 医学化学
- 抗菌研究 抗菌研究
背景情况:
- 越来越多的细菌耐药性需要新的抗菌剂.
- 希夫基金属复合物因其独特的结构和机制而被探索其抗菌潜力.
- 以前的研究表明,希夫基金属复合物可以破坏细菌细胞壁和膜.
研究的目的:
- 从硫甲和素合成和描述一种新的希夫基 (L).
- 开发希夫基L与铜 (Cu2+), (Co2+), (Ni2+) 和 (Cd2+) 的金属复合物.
- 评估合成的希夫基及其金属复合物的抗菌和抗真菌活性.
主要方法:
- 使用NMR,质谱学,UV-Vis和FTIR合成和描述希夫基L及其金属复合物.
- 对细菌菌株 (大肠杆菌,黄金色,P. aeruginosa) 和真菌菌株 (C. albicans) 的抗菌活性测试.
- 密度函数理论 (DFT) 计算以调查希夫基L的分子性质.
主要成果:
- 基于铜的化合物1显示出强大的抗真菌活性.
- 基于的化合物3显示出针对Pseudomonas aeruginosa的显著抗菌疗效.
- 所有的金属复合物在抗真菌试验中都表现优于原始希夫基,但在抗菌试验中没有一个超越了西普洛素.
结论:
- 希夫基础金属复合物,特别是铜和衍生物,显示出相当有前途的抗菌剂.
- 合成的化合物为对抗耐药性细菌感染提供了潜在的新途径.
- 建议对潜在的临床应用进行进一步的研究和优化.
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