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基于线粒体代谢相关基因的喉平细胞癌的预后模型

Wei-Ming Hu¹, Wen-Jing Jiang¹

¹Head and Neck & Otolaryngology Center, Plastic Surgery Center, Cancer Center, Department of Otolaryngology, Zhejiang Provincial People's Hospital, Hangzhou, China.

Translational cancer research

|March 19, 2025

概括

与线粒体代谢相关的基因 (MMRGs) 可以预测喉状细胞癌 (LSCC) 的结果. 一个四基因模型确定了具有较差生存率的高风险患者,这表明MMRGs是LSCC的潜在治疗生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
代谢途径代谢途径

背景情况:

与线粒体代谢相关的基因 (MMRGs) 越来越多地被认为对癌症发展起着作用.
喉平细胞癌 (LSCC) 是一个重要的全球健康问题.
识别新的预后标志物对于改善LSCC患者的治疗结果至关重要.

研究的目的:

为使用MMRGs开发LSCC患者的预后模型.
在LSCC中调查关键MMRG的功能角色和监管网络.
在LSCC中探索MMRG与瘤免疫微环境和药物敏感性的关联.

主要方法:

在LSCC中使用TCGA和MSigDB数据集对MMRG的微分表达式分析.
功能丰富分析 (GO,KEGG) 和通过考克斯回归 (单变量,LASSO,多变量) 构建预后模型.
使用卡普兰-梅尔和ROC曲线的验证;GSEA,GPSA和对免疫微环境和药物敏感性的相关性分析.

主要成果:

确定了308种参与代谢过程的不同表达的MMRG.
开发了一个四个枢纽基因预后模型 (POLD1,PON2,SMS,THEM5),准确预测LSCC患者的存活率.
在高风险和低风险组之间观察到不同的免疫微环境概况和药物敏感性,与特定的MMRG表达模式相关.

结论:

在LSCC中,MMRG,特别是POLD1,PON2,SMS和THEM5具有显著的预后价值.
开发的基于MMRG的模型为预测LSCC患者的结果提供了一个有希望的工具.
这些发现强调了MMRG作为LSCC治疗策略的潜在治疗目标和生物标志物.

关键词:

喉平细胞癌 (LSCC) 是一种免疫微观环境免疫微环境线粒体代谢相关基因 (MMRG)突变是一种突变.预后预后预后

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