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父亲和母亲暴露在Per-和多基物质和儿童行为困难:父母对比研究

Pengfei Guo^1,2, Jiajun Luo^3,4, Jie Zhang⁵

¹Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06510, United States.

Environmental science & technology

|March 19, 2025

概括

孕妇在怀孕期间暴露在per-和多基物质 (PFAS) 中,与儿童的行为问题有关. 父亲的PFAS暴露与后代的神经发育结果没有关联.

科学领域:

环境健康环境健康
发育毒理学发展毒理学
生殖流行病学生殖流行病学

背景情况:

透和多基基物质 (PFAS) 是普遍存在的环境污染物.
众所周知,PFAS是发育性毒素,但父亲暴露对后代神经发育的影响还未得到充分研究.
关于产前PFAS暴露和儿童神经发育的现有研究尚未充分探索父母的影响.

研究的目的:

调查母亲和父亲对PFAS产前暴露和儿童行为困难之间的关联.
检查父母PFAS暴露对后代神经发育的性别特异性影响.
为了区分母亲与父亲的PFAS暴露对儿童行为结果的影响.

主要方法:

研究包括来自INUENDO队列 (格陵兰,波兰,乌克兰) 的334个父亲-母亲-单身三合体.
母亲和父亲的血清PFAS水平在怀孕31周左右被测量.
儿童的行为困难 (5-9岁) 用家长评级的强度和困难问卷进行评估;分析按儿童性别分层,并使用量子式g计算来计算混合效应.

主要成果:

母亲接触多种PFAS (单独或作为混合物) 与男性儿童的外部化行为困难有关.
孕产妇暴露于 perfluorononanoic acid (PFNA) 与女性儿童内化困难有关.
在父 PFAS 暴露 (个人或混合) 与儿童行为困难之间没有发现显著的关联.

结论:

母亲产前的PFAS暴露,但不是父亲的暴露,与童年中期的性别特异性行为困难有关.
调查结果强调了母亲暴露的重要性,并建议在考虑父母特异性影响时,从共同的家庭因素中减少混.
这项研究提供了证据,区分母亲与父亲的PFAS暴露对神经发育的影响.

关键词:

孩子的行为孩子的行为内分泌干扰物干扰内分泌干扰物增长和发展增长和发展父亲暴露的情况.怀孕怀孕怀孕怀孕

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