在患有阻塞性睡眠呼吸暂停的患者中,过度白天嗜睡的管理选择
Maria R Bonsignore1,2, Francesco Fanfulla3, Pietro Ingrao1
1PROMISE Department, University of Palermo, Palermo, Italy.
Expert review of respiratory medicine
|March 19, 2025
概括
在阻塞性睡眠呼吸暂停 (OSA) 患者中,过度的白天嗜睡 (EDS) 可能在治疗后仍然存在. 新的唤醒促进剂 (WPAs) 提供了治疗选择,但建议专家管理以获得最佳结果.
科学领域:
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 过度的白天嗜睡 (EDS) 是阻塞性睡眠呼吸暂停 (OSA) 患者的常见症状,增加了意外风险.
- 虽然OSA治疗可以减少EDS,但有些患者会经历持续的嗜睡.
- 不愿或无法使用OSA治疗的患者可能需要症状EDS管理.
研究的目的:
- 审查OSA患者残留EDS的评估,流行病学和管理.
- 介绍最近关于新兴唤醒剂 (WPAs) 对于昏昏欲睡的OSA患者的研究结果.
- 讨论WPAs在接受或拒绝持续正气道压力 (CPAP) 治疗的OSA患者中的作用.
主要方法:
- 通过PubMed.com访问文献的叙事综述.
- 在2024年12月1日至2025年1月6日期间进行的文献搜索.
主要成果:
- 索里亚美醇和皮托利桑特是新批准的WPA,用于睡眠不良的OSA患者.
- 这些WPA展示了有利的安全概况.
- 关于受益于WPAs最多的特定患者子组的数据仍在出现.
结论:
- 新的WPA代表了在OSA患者中管理持续EDS的有价值的治疗选择.
- 需要仔细考虑,以确定WPA的最佳候选人,以减轻OSA的健康风险.
- 在OSA患者中WPA的管理应由睡眠专家监督.
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