经过对晚期ALS进行修改的中央部分喉切除术后,改善了喉收缩和口服状态
Rumi Ueha1,2, Maria Angela Dealino2, Misaki Koyama2
1Swallowing Center, The University of Tokyo Hospital, Tokyo, Japan.
概括
经过修改的中部喉切除术与喉空间缩小 (CPL-PR) 在晚期肌缩侧面硬化症 (ALS) 患者中改善了吞功能和口服摄入. 这种手术选择有助于预防吸血并恢复口服养能力.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 晚期肌缩性侧面硬化症 (ALS) 通常会导致严重的喉软弱和消化不良.
- 在ALS中吞障碍增加了吸入风险,并阻碍了口服.
研究的目的:
- 评估ALS患者修改的中部喉切除与喉空间缩小 (CPL-PR) 的疗效.
- 评估CPL-PR对喉收缩,玻尿酸通道和口服的影响.
主要方法:
- 追溯18名晚期ALS患者的病例系列,这些患者接受了CPL-PR.
- 分析了手术前和手术后的视频光学吞研究 (VFSS) 和高分辨率手术光学.
- 透吸收量表 (PAS) 和功能性口服摄入量表 (FOIS) 的得分进行了比较.
主要成果:
- 口服摄入量显著改善 (术后3个月FOIS得分从1增加到3).
- 增强了喉关闭和中低喉收缩.
- 减少上食道关节 (UES) 的休息压力和延长UES放松时间.
结论:
- CPL-PR导致喉收缩和UES球体通道的明显改善.
- 该程序有助于恢复晚期ALS患者的口服摄入.
- CPL-PR是可行的手术选择,用于需要气管切除术以防止吸入和促进口服养的ALS患者.
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