导致尿路感染的B组菌的多药性耐药性暴露了由红红素驱动的抗氧化应激保护作用
Devika Desai1,2, Kelvin G K Goh1,2, Sandon Ranadeera1,2
1School of Pharmacy and Medical Sciences, Griffith University, Gold Coast Campus, Southport 4222, QLD, Australia.
Journal of medical microbiology
|March 19, 2025
概括
来自尿路感染的多药耐药B组链球菌 (GBS) 对常见抗生素具有很高的耐药性. 令人惊的是,红色素暴露部分保护了这些细菌免受过氧化引起的氧化应激.
科学领域:
- 微生物学 微生物学
- 抗生素耐药性 抗生素耐药性
- 传染性疾病 传染性疾病
背景情况:
- 乙组链球菌 (GBS) 是一个重要的病原体,在全球范围内报告了越来越多的抗药性 (MDR).
- 了解GBS尿路感染 (UTI) 隔离物中的MDR率对于有效的治疗策略至关重要.
- 红素是一种二线GBS抗生素,已经显示出可能影响细菌对氧化应激的耐药性.
研究的目的:
- 为了确定在尿路感染 (UTI) 孤立体中多药耐药 (MDR) GBS的患病率.
- 调查红色素暴露对MDR GBS氧化应激抵抗性的影响.
主要方法:
- 测试了18种抗生素的抗菌活性,对292种GBS尿路感染分离物使用磁盘扩散进行了测试.
- 在体外生长试验中,对暴露于红红和过氧化 (H2O2) 的MDR GBS进行了增长试验.
主要成果:
- 33.6%的GBS分离物具有多药耐药性 (MDR),对阿齐思罗米辛,克林达米辛,红色素和四环素具有很高的耐药性.
- 根据临床来源 (急性尿路感染,复发性尿路感染,无症状细菌尿症) 抗药率没有显著变化.
- 暴露于红色素部分抵消了H2O2在MDR GBS上的增长抑制作用.
结论:
- 隔离的GBS尿路感染表现出大量的多药性耐药性,独立于临床来源.
- 红素暴露可以在一定程度上保护MDR GBS免受氧化应激,这表明抗生素和细菌防御机制之间的复杂相互作用.
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