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探索编码生长因子的基因中的多态性,与非综合征裂唇相关,有或没有裂 palatus 和牙生成
Gabriela Fonseca-Souza1, Vitória Somma Tessari1, Rafaela Scariot1
1Universidade Federal do Paraná, Setor de Ciências da Saúde, Departamento de Estomatologia, Curitiba, Paraná, Brasil.
带有或没有裂口的非综合性裂口 (NSCL±P) 与裂口区域外的牙发生 (TA) 有关. 皮表皮生长因子 (EGF) 基因多态化rs2237051与NSCL±P有关,但不是TA.
科学领域:
- 口腔和牙面部外科手术
- 儿科牙科 儿科牙科
- 人类遗传学 人类遗传学
背景情况:
- 带有或没有裂口的非综合性裂口 (NSCL±P) 是一种常见的先天性异常.
- 牙发育 (TA),牙的先天性缺失,可以独立发生或与各种综合征相关.
- NSCL±P和TA之间的潜在关联,特别是裂区域外发生的TA,需要进行调查.
研究的目的:
- 评估NSCL±P和TA之间的关联.
- 评估NSCL±P和TA与生长因子基因中的特定遗传多态的关联.
- 要确定EGF rs2237051是否与NSCL±P有关,以及TA是否与遗传多态性有关.
主要方法:
- 这是一项横截面研究,比较了患有NSCL±P和没有NSCL±P的儿童.
- 在NSCL±P组中,全景放射被用于诊断TA,不包括第三牙,并专注于裂外的区域.
- 在TGFB1,TGFBR2,EGF和EGFR基因中的多态的基因定型使用实时PCR进行.
主要成果:
- 与对照组 (6.2%) 相比,NSCL±P (23.8%) 的儿童的牙发育 (TA) 发生频率明显高.
- 表皮生长因子 (EGF) 基因多态 rs2237051 与NSCL±P显著相关.
- 在TA和研究的遗传多态体之间没有发现显著的关联,尽管在TA/NSCL±P和TGFB1 rs1800470.0之间注意到了边界关联.
结论:
- NSCL±P与发生在裂区域外的TA有关.
- 根据EGF rs2237051的多态性与NSCL±P有关.
- 研究的生长因子基因多态性与TA无关.
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