药物遗传学可以用来预测对费索特罗丁酸盐的反应吗?
Jennifer M Wu1, Nazema Y Siddiqui2, Tim Wiltshire3
1From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics & Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
药物遗传学研究表明,CYP2D6代谢器状态不会影响festerodine的有效性或急性尿失禁 (UUI) 的妇女的不良事件. 由于代谢不良物质的数量较少,需要进行进一步的研究.
科学领域:
- 药理学 药理学是指药理学的学科.
- 遗传学 是一个遗传学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 紧急尿失禁 (UUI) 影响了许多女性,预测抗胆固醇药物如费索托丁的治疗反应是具有挑战性的.
- 药物遗传学提供了一个潜在的途径,通过了解个体药物代谢来个性化UUI治疗.
- 细胞染色体P450 2D6 (CYP2D6) 是 fesoterodine代谢中的一个关键酶.
研究的目的:
- 调查CYP2D6代谢器状态与UUI妇女的费索托罗丁治疗的有效性之间的关联.
- 为了评估CYP2D6代谢器状态和中度至重度不良事件 (AEs) 的发生之间的关系,在女性UUI治疗 fesoterodine.
主要方法:
- 一项试点药物遗传学研究,涉及58名50岁及以上的女性,患有UUI.
- 参与者对CYP2D6进行基因定型,以确定他们的代谢器状态:正常 (NM),中间 (IM) 或差 (PM).
- 使用治疗益处量表来评估有效性,并根据国家癌症研究所常用术语标准对不良事件进行AEs分级.
主要成果:
- 该研究包括34个NM,22个IM和2个PM.
- 在4周内,NM和IM组之间没有观察到UUI治疗有效性的显著差异 (82.8%对94.4%,P=0.38).
- 代谢器状态与中度至重度的副作用没有关联 (14.7%对NM和IM的13.6%,P=1.0).
结论:
- 在这项试点研究中,CYP2D6正常和中间代谢器状态与Fesoterodine有效性或UUI妇女的副作用没有相关性.
- 低代谢率的低患病率限制了最终的结论.
- 需要使用更大的样本大小进行进一步的研究,以充分探索CYP2D6在UI药物遗传学中的作用.
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