展望未来:环极和基于环极的药物输送到视网膜
Phatsawee Jansook1,2, Hákon H Sigurdsson3, Thorsteinn Loftsson3
1Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
Expert opinion on drug delivery
|March 19, 2025
概括
基于循环德克斯 (CD) 的纳米颗粒为治疗视网膜疾病提供了一种非侵入性,患者友好的替代方案. 这些先进的眼液增强了药物输送,改善了视力损失治疗和眼部生物可用性.
科学领域:
- 眼科医生 眼科 眼科
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 视网膜疾病导致全球显著的视力丧失.
- 目前的治疗方法,如内注射,是侵入性的.
- 非侵入性局部分娩面临着眼睛障碍.
研究的目的:
- 审查用于眼部药物输送的基于循环德素 (CD) 的纳米粒子.
- 探索CD作为制药辅助剂和活性剂.
- 为了突出基于CD的眼滴配方的进步.
主要方法:
- 对眼科中CD应用的当前文献的综述.
- 对CD纳米粒子配方进行分析,以提高眼部生物可用性.
- 对基于CD的眼滴的临床试验数据的检查.
主要成果:
- CD纳米粒子有效地提高了眼睛后部部分的药物透性.
- 磁盘可以提高眼部药物的生物可用性,克服输送障碍.
- 几种基于CD的眼滴配方正在临床开发中.
结论:
- 基于CD的纳米粒子眼滴是一种有希望的,临床上成功的治疗策略.
- CDs作为批准的辅助剂和视网膜疾病的潜在活性剂.
- 未来的创新将集中在针对性视网膜疾病治疗的混合系统上.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
296
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
296
01:16Drug Delivery: Overview
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
270