潜在的膀刺激物和过度活跃的膀症状:一个系统的审查
Barbara Ha1, Yoolim Seo2, Ashlee M Weaver3
1From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Urogynecology (Philadelphia, Pa.)
|March 19, 2025
概括
这次审查没有找到一致的证据,将酒精或人工甜味剂等常见的膀刺激物与过度活跃的膀症状联系起来. 需要进一步的研究来澄清它们在治疗这种疾病中的作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 饮食科学 饮食科学
- 基于证据的医学基于证据的医学.
背景情况:
- 行为修改,包括避免膀刺激物,是过度活性膀 (OAB) 的首要治疗策略.
- 特定的饮食刺激物在OAB中的确切作用尚不清楚,需要进一步的研究,正如2017年国际 incontinence咨询所强调的那样.
研究的目的:
- 系统地审查和评估现有的同行评审文献.
- 为了检查六种潜在的膀刺激物和OAB症状之间的关联.
- 综合有关OAB的酒精,辛食品,巧克力,人工甜味剂,咖啡因/碳酸/类饮料和高酸性食品的发现.
主要方法:
- 在MEDLINE,EMBASE和SCOPUS数据库中进行了系统的文献搜索.
- 一个适应的患者干预-比较-结果框架指导了审查.
- 使用非随机化暴露研究中的偏差风险工具评估了偏差风险;该研究已注册PROSPERO (CRD42023466251).
主要成果:
- 审查了51篇文章,重点关注酒精 (34),辛食品 (1),巧克力 (3),人工甜味剂 (5),饮料 (27),高酸性食品 (2).
- 评估的结果包括OAB,急性失禁,尿急性,频率和夜尿.
- 观察到这些刺激物和OAB症状之间的关联是混合的和不一致的,在23个出版物中存在中度偏差风险.
结论:
- 这一系统性审查没有找到一致的证据来支持研究的膀刺激物与过度活跃的膀症状之间的关联.
- 目前的证据不足以最终将特定的饮食成分与OAB症状恶化联系起来.
- 需要进一步进行高质量的研究,以阐明这些刺激物对OAB的潜在影响.
相关概念视频
01:26The Micturition Reflex
353
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
353
01:20Disorders of the Urinary System
201
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
201
01:23Urinary Bladder
287
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
287
01:17Irritable Bowel Syndrome I: Introduction
211
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
211
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
102
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
102
01:24Physiology of Urine Formation
2.5K
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
2.5K