重复低剂量LSD在成人多动症治疗中的安全性和有效性:一项随机临床试验
Lorenz Mueller1,2, Joyce Santos de Jesus1,2, Yasmin Schmid1,2
1Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.
JAMA psychiatry
|March 19, 2025
概括
对注意力缺陷/多动性障碍 (ADHD) 的微剂量lysergic acid diethylamide (LSD) 发现是安全的,但不比安慰剂更有效. 这项为期6周的试验显示,在LSD和安慰剂组之间,症状减轻没有显著差异.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 微剂量的迷幻药物,如 lysergic acid diethylamide (LSD) 正在用于精神疾病的研究中.
- 注意缺陷/多动障碍 (ADHD) 是一种目前尚不清楚LSD功效的疾病.
- 需要研究LSD在管理ADHD症状中的潜在治疗效果.
研究的目的:
- 评估重复低剂量lysergic acid diethylamide (LSD) 给患有注意力缺陷/多动症障碍 (ADHD) 的成年人的安全性和疗效.
- 为了比较LSD微量剂与安慰剂在6周内减少ADHD症状的影响.
主要方法:
- 进行了为期6周的多中心,双盲,安慰剂控制,并行组2A期随机临床试验.
- 患有中度至重度ADHD症状的参与者 (N=53) 每周两次接受20微克LSD或安慰剂.
- 用成年调查者症状评分表 (AISRS) 评估ADHD症状的变化,并用混合效应模型分析重复测量.
主要成果:
- 在LSD组 (改善7.1分) 和安慰剂组 (改善8.9分) 之间,没有观察到ADHD症状平均改善 (AISRS得分) 的统计学上显著差异.
- 莱瑟基酸二甲基胺 (LSD) 的使用在门诊环境中被发现是身体安全的,并且在心理上被容忍得很好.
- 这项研究包括53名参与者,其中27名被随机分配给LSD,26名被分配给安慰剂,平均年龄为37岁,42%是女性.
结论:
- 在门诊环境中,重复服用低剂量的lysergic acid diethylamide (LSD) 对患有注意力缺陷/多动症障碍 (ADHD) 的成年人是安全的.
- 这项研究没有发现证据表明微剂量LSD在减少ADHD症状方面比安慰剂更有效.
- 可能需要进一步的研究来探索其他剂量或涉及LSD治疗ADHD的治疗方法.
更多相关视频
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
5.7K
08:22Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
Published on: October 7, 2017
8.0K
相关概念视频
01:30Attention-Deficit/Hyperactivity Disorder
50
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
50
01:27Hallucinogens and Psychedelics
158
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
158