长期COVID:新出现的病理生理机制
Michael R Mueller1, Ravindra Ganesh2, Thomas J Beckman2
1Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA - mueller.michael@mayo.edu.
后COVID条件,或长COVID,涉及各种症状,如疲劳和脑雾感染后持续. 了解长期COVID的各种原因和潜在治疗方法对于患者的康复至关重要.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 后COVID状况 (长期COVID) 代表了一组复杂,异质的症状,在感染后28天内持续存在.
- 这些状况极大地导致了全球的发病率和功能限制,影响了全世界数以百万计的人.
- 长期COVID的潜在病理生理学和有效治疗方法在很大程度上仍未定义.
研究的目的:
- 提出一个概念框架来评估与长期COVID相关的各种症状.
- 审查支持建议的病理生理机制推动长期COVID的证据.
- 根据机理学可信性,讨论长期COVID的潜在治疗策略.
主要方法:
- 长期COVID的拟议病理生理机制的文献综述和综合.
- 长期COVID患者症状评估的概念框架开发.
- 分析证据,将拟议的机制与临床表现联系起来.
主要成果:
- 多种病理生理路径与长期COVID有关,包括神经炎症,内皮功能障碍和自主功能障碍.
- 患者表现不同,不同机制的贡献在个体上有所不同.
- 目前没有FDA批准的治疗方法用于长期的COVID.
结论:
- 对长期COVID的全面理解需要考虑多种,可能重叠的病理生理驱动因素.
- 提出了一个结构化的评估框架,以指导长期COVID症状的评估.
- 机械学上可信的疗法显示出希望,为长期的COVID治疗保证了进一步的调查.
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