抗氧化纳米颗粒诱导的小鼠脏损伤的N-乙半氨酸的保护作用

抗氧化纳米颗粒诱导的小鼠脏损伤的N-乙半氨酸的保护作用

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Cengiz Yuksel^1,2, Yesim Hulya Uz³

¹Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Journal of molecular histology

|March 19, 2025

概括

N-乙半氨酸 (NAC) 保护氧化物纳米颗粒 (TiO2NP) 造成的损伤. NAC可减少炎症和细胞死亡,减轻老鼠脏中的TiO2NP毒性.

科学领域:

毒理学毒理学毒理学
纳米医学是一种纳米医学.
腎臟健康腎臟健康

背景情况:

二氧化纳米颗粒 (TiO2NP) 在消费品中越来越普遍.
暴露于TiO2NP的潜在毒性需要彻底调查.
N-乙半氨酸 (NAC) 以其抗氧化和抗炎性质而闻名.

研究的目的:

研究N-乙半氨酸 (NAC) 对由二氧化纳米颗粒 (TiO2NP) 引起的损伤的保护作用.
评估在TiO2NP暴露和NAC治疗后,大鼠脏的生物化学,组织学和免疫组织化学变化.

主要方法:

40只大鼠被分为四组:对照组,NAC组,TiO2NP组和TiO2NP+NAC组.
TiO2NP是通过胃内注射的,而NAC是通过腹腔内注射的.
用生物化学标记物,组织学检查和针对炎症和亡标记物的免疫组织化学分析来评估损伤.

主要成果:

TiO2NP暴露显著增加了管损伤,炎症和亡 (NF-kB,TNF-α,caspase-3,TUNEL阳性细胞的增加).
NAC治疗显著改善了TiO2NP诱导的组织损伤,并减少了炎症和亡标志物.
NAC并没有改变体重,脏体重,血清尿素-肌素或PCNA阳性细胞计数.

结论:

N-乙半氨酸 (NAC) 显示出对二氧化纳米颗粒 (TiO2NP) 诱导的毒性有显著的保护作用.
纳克的抗炎和抗亡性质是缓解TiO2NP损伤的关键机制.
这些发现表明NAC是一种潜在的治疗剂,可以抵消TiO2NP暴露对脏的不良影响.

关键词:

这是一种N-乙囊氨酸.细胞灭亡 (apoptosis) 是一种死亡的过程.脏 - 脏 - 脏在 NF-kBB 中.这就是TNF-α.二氧化纳米颗粒的二氧化.

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